B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

The somatic hypermutation (SHM) status of the clonotypic immunoglobulin heavy variable
(IGHV) gene is a critical biomarker for assessing the prognosis of patients with chronic …

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

Recent evidence suggests that complex karyotype (CK) defined by the presence of≥ 3
chromosomal aberrations (structural and/or numerical) identified by using chromosome …

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

Signals emanating from the B‐cell receptor (BCR) promote proliferation and survival in
diverse forms of B‐cell lymphoma. Precision medicine strategies targeting the BCR pathway …

The discovery of almost identical or 'stereotyped'B-cell receptor immunoglobulins (BcR IG)
among unrelated patients with chronic lymphocytic leukemia (CLL) cemented the idea of …

Pivotal studies from the 1990s offered the first pieces of evidence for the role of
immunoglobulin (IG) receptors and antigen stimulation in the natural history of chronic …

Cell-autonomous B-cell receptor (BcR)-mediated signalling is a hallmark feature of the
neoplastic B lymphocytes in chronic lymphocytic leukaemia (CLL). Here we elucidate the …

Almost one-third of all patients with chronic lymphocytic leukemia (CLL) express stereotyped
B-cell receptor immunoglobulins (BcR IG) and can be assigned to distinct subsets, each with …