Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification
The broad range of tissue and cellular diversity of animals is generated to a large extent by
the hierarchical deployment of sequence‐specific transcription factors and co‐factors …
the hierarchical deployment of sequence‐specific transcription factors and co‐factors …
Evolution of patterning systems and circuit elements for locomotion
Evolutionary modifications in nervous systems enabled organisms to adapt to their specific
environments and underlie the remarkable diversity of behaviors expressed by animals …
environments and underlie the remarkable diversity of behaviors expressed by animals …
Hox proteins coordinate motor neuron differentiation and connectivity programs through Ret/Gfrα genes
The accuracy of neural circuit assembly relies on the precise spatial and temporal control of
synaptic specificity determinants during development. Hox transcription factors govern key …
synaptic specificity determinants during development. Hox transcription factors govern key …
Variability in Neural Circuit Formation
KJ Mitchell - Cold Spring Harbor Perspectives in Biology, 2024 - cshperspectives.cshlp.org
The study of neural development is usually concerned with the question of how nervous
systems get put together. Variation in these processes is usually of interest as a means of …
systems get put together. Variation in these processes is usually of interest as a means of …
Transcriptional control of long-range cortical projections
Highlights•Neuronal identity is regulated by combinatorial sets of gene expression under
transcriptional regulation.•Long-range cortical projections develop by dynamic interactions …
transcriptional regulation.•Long-range cortical projections develop by dynamic interactions …
SNARE complex in axonal guidance and neuroregeneration
F Ulloa, T Cotrufo, D Ricolo, E Soriano… - Neural regeneration …, 2018 - journals.lww.com
Through complex mechanisms that guide axons to the appropriate routes towards their
targets, axonal growth and guidance lead to neuronal system formation. These mechanisms …
targets, axonal growth and guidance lead to neuronal system formation. These mechanisms …
Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos
J Velten, X Gao, P Van Nierop y Sanchez… - Molecular Systems …, 2022 - embopress.org
The correct wiring of neuronal circuits is one of the most complex processes in development,
since axons form highly specific connections out of a vast number of possibilities. Circuit …
since axons form highly specific connections out of a vast number of possibilities. Circuit …
Switching responses: spatial and temporal regulators of axon guidance
The ability of the axonal growth cone to switch between attraction and repulsion in response
to guidance cues in the extracellular environment during nervous system development is …
to guidance cues in the extracellular environment during nervous system development is …
A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection
Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing
nervous system; however, how these factors impinge on surface molecules that control …
nervous system; however, how these factors impinge on surface molecules that control …
The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections
C Hessinger, GM Technau… - Development, 2017 - journals.biologists.com
Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord
and to control motoneuronal targeting in several species. However, the mechanisms …
and to control motoneuronal targeting in several species. However, the mechanisms …