Telomerase plays a pivotal role in bypassing cellular senescence and maintaining telomere
homeostasis, essential properties required for the sustenance and progression of cancer …

Telomerase plays a critical role in stem cell function and tissue regeneration that depends
on its ability to elongate telomeres. For nearly two decades, it turned out that TERT regulates …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Abstract Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting
protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays …

Proper replication of the telomeric DNA at chromosome ends is critical for preserving
genome integrity. Yet, telomeres present challenges for the replication machinery, such as …

Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …

Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide
sequences in humans. Telomeres preserve chromosomal stability and genomic integrity …

Telomeres protect chromosome ends from degradation and inappropriate DNA damage
response activation through their association with specific factors. Interestingly, these …

Telomere maintenance is essential for maintaining genome integrity in both normal and
cancer cells. Without functional telomeres, chromosomes lose their protective structure and …

Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …