Antimalarial quinoline drugs inhibit β-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
Recent metabolomic developments for antimalarial drug discovery
L Mamede, F Fall, M Schoumacher, A Ledoux… - Parasitology …, 2022 - Springer
Malaria is a parasitic disease that remains a global health issue, responsible for a significant
death and morbidity toll. Various factors have impacted the use and delayed the …
death and morbidity toll. Various factors have impacted the use and delayed the …
The knock-down of the chloroquine resistance transporter PfCRT is linked to oligopeptide handling in Plasmodium falciparum
CP Sanchez, EDT Manson, S Moliner Cubel… - Microbiology …, 2022 - Am Soc Microbiol
The chloroquine resistance transporter, PfCRT, is an essential factor during intraerythrocytic
development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the …
development of the human malaria parasite Plasmodium falciparum. PfCRT resides at the …
Global spread of mutant PfCRT and its pleiotropic impact on Plasmodium falciparum multidrug resistance and fitness
SK Dhingra, SJ Gabryszewski, JL Small-Saunders… - MBio, 2019 - Am Soc Microbiol
The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT)
variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia …
variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia …
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum …
LM Hagenah, SK Dhingra, JL Small-Saunders… - Mbio, 2024 - Am Soc Microbiol
Malaria elimination efforts in Southeast Asia have been hindered by multidrug-resistant
Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination …
Plasmodium falciparum. High-grade resistance to piperaquine (PPQ, used in combination …
[PDF][PDF] Global spread of mutant PfCRT and its pleiotropic impact on Plasmodium falciparum multidrug resistance and fitness. mBio 10: e02731-18
SK Dhingra, SJ Gabryszewski, JL Small-Saunders… - 2019 - researchgate.net
The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT)
variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia …
variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia …