Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Nirmatrelvir is a specific antiviral drug that targets the main protease (Mpro) of SARS-CoV-2
and has been approved to treat COVID-19,. As an RNA virus characterized by high mutation …

Ferroptosis, as a type of programmed cell death process, enables effective damage to
various cancer cells. However, we discovered that persistent oxidative stress during …

Ferroptosis is a regulated form of cell death associated with the iron-dependent
accumulation of phospholipid hydroperoxides. Inducing ferroptosis is a promising approach …

Multimodal therapy requires effective drug carriers that can deliver multiple drugs to specific
locations in a controlled manner. Here, the study presents a novel nanoplatform constructed …

Blocking cancer genomic instability may prevent tumor diversification and escape from
therapies. We show that, after MAPK inhibitor (MAPKi) therapy in patients and mice bearing …

Tumors driven by deficiency of the VHL gene product, which is involved in degradation of
the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for targeted …

Tumor cells harness Ca2+ to maintain cellular homeostasis and withstand external stresses
from various treatments. Here, a dual‐channel Ca2+ nanomodulator (CAP‐P‐NO) is …

The drug-tolerant persister (DTP) state enables cancer cells to evade cytotoxic stress from
anticancer therapy. However, the mechanisms governing DTP generation remain poorly …