Borrelia burgdorferi is the causative agent of Lyme disease and is transmitted to vertebrate
hosts by Ixodes spp. ticks. The spirochaete relies heavily on its arthropod host for basic …

Since the discovery of the Lyme disease spirochete in North America in 1982 and in Europe
in 1983, a plethora of studies on this unique group of spirochetes that comprise Borrelia …

Abstract The Lyme disease agent Borrelia burgdorferi naturally persists in a cycle that
primarily involves ticks and mammals. We have now identified a tick receptor (TROSPA) that …

Environmentally responsive synthesis of surface proteins represents a hallmark of the
infectious cycle of the Lyme disease agent, Borrelia burgdorferi. Here we created and …

The spirochete Borrelia burgdorferi is a tick-borne obligate parasite whose normal reservoir
is a variety of small mammals. Although infection of these natural hosts does not lead to …

Outer surface protein C (OspC) is a differentially expressed major surface lipoprotein of
Borrelia burgdorferi. ospC is swiftly upregulated when spirochetes leave the Ixodes …

Lyme borreliosis is increasing rapidly in many parts of the world and is the most commonly
occurring vector-borne disease in Europe and the USA. The disease is transmitted by ticks …

The molecular basis of how Borrelia burgdorferi (Bb), the Lyme disease spirochete,
maintains itself in nature via a complex life cycle in ticks and mammals is poorly understood …

The analysis of different multi-host systems suggests that even hosts that are not capable of
transmitting Borrelia burgdorferi sensu lato (sl.) to the tick vector, Ixodes ricinus, or that are …

ABSTRACT A major obstacle to studying the functions of particular gene products in the
mouse-tick infectious cycle of Borrelia burgdorferi has been an inability to knock out genes …