Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

In addition to their role in protein degradation and digestion, proteases can also function as
hormone-like signaling molecules that regulate vital patho-physiological processes …

The coagulation cascade is activated during viral infections. This response may be part of
the host defense system to limit spread of the pathogen. However, excessive activation of …

Obesity is a growing epidemiological problem, as two-thirds of the adult population are
carrying excess weight. It is a risk factor for the development of cardiovascular diseases …

Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

The extracellular matrix (ECM) is a complex and dynamic scaffold that maintains tissue
structure and dynamics. However, the view of the ECM as an inert architectural support has …

Cardiovascular diseases, including atherothrombosis, are the leading cause of morbidity
and mortality in the United States, Europe, and the developed world. Matrix …

Protease signaling in cells elicits multiple physiologically important responses via protease-
activated receptors (PARs). There are 4 members of this family of G-protein–coupled …

Coagulation is a host defense system that limits the spread of pathogens. Coagulation
proteases, such as thrombin, also activate cells by cleaving PARs. In this study, we analyzed …

Mice fully deficient in peptidylarginine deiminase 4 (PAD4) enzyme have preserved cardiac
function and reduced collagen deposition during ageing. The cellular source of PAD4 is …