Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients
with (quasi) identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain …

The ontogeny and evolution of chronic lymphocytic leukemia (CLL) are critically dependent
on interactions between leukemic cells and their microenvironment, including antigens, the …

Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene
rearrangement sequences in patients with mature B cell neoplasms has led to the …

Identifying local similarities in binding sites from distant proteins is a major hurdle to rational
drug design. We herewith present a novel method, borrowed from computer vision, adapted …

The repertoires of B cell receptors (BCRs), which can be captured by single cell-resolution
sequencing technologies, contain a personal history of a donor's antigen exposure. One of …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the West,
characterized by the clonal expansion and accumulation of mature B cells in the a Institute of …

Misfolded proteins result when a protein follows the wrong folding pathway. Accumulation of
misfolded proteins can cause disorders, known as amyloid diseases. Unfortunately, some of …

Adaptive immune receptor repertoire (AIRR) data is used for research into the immune
system. immuneML is a machine learning platform used for analysis of adaptive immune …

Healthcare has seen massive data growth over the last several years, with some reports
estimating that healthcare data generation increases by 48% annually. The advent of …

Proteins have a significant role in all biological processes. The functional properties of
proteins rely upon their three-dimensional structures. Over the last twenty years substantial …