This review is in support of the development of selective, precise, fast, and validated
capillary electrophoresis (CE) methods. It follows up a similar article from 1998, Wätzig H …

This review provides a comprehensive overview of methodological advances and
applications of CE in the analysis and characterization of recombinant therapeutic and …

Imaged capillary isoelectric focusing (icIEF) and ion-exchange chromatography (IEX) are
two essential techniques that are routinely used for charge variant analysis of therapeutic …

Proteins are efficient therapeutic agents and attractive potential new biomarkers due to their
physiological and pathological functions. Further, biopharmaceuticals feature complex …

Capillary isoelectric focusing (cIEF) is a very powerful separation technique. However,
successful implementation of this technique in various fields of science requires a few …

Imaged capillary isoelectric focusing (icIEF) technology has been proved to be robust for the
characterization of protein charge heterogeneity due to its high-resolution pI discrimination …

Isoelectric focusing (IEF) is a powerful tool for resolving complex protein samples, which
generates IEF patterns consisting of multiplex analyte bands. However, the interpretation of …

The characterization of cysteine-linked antibody‒drug conjugates (ADCs) can be more
challenging than that of monoclonal antibodies (mAbs) and lysine-linked ADCs because the …

Characterizing major bovine milk proteins, including whey and casein, is of significant
interest in the dairy industry. The diverse array of protein proteoforms can be different in …

Post‐translational modifications (PTMs) of adeno‐associated virus (AAV) capsid proteins
tune and regulate the AAV infective life cycle, which can impact the safety and efficacy of …