[HTML][HTML] The application of whole cell-based biosensors for use in environmental analysis and in medical diagnostics

Q Gui, T Lawson, S Shan, L Yan, Y Liu - Sensors, 2017 - mdpi.com
Various whole cell-based biosensors have been reported in the literature for the last 20
years and these reports have shown great potential for their use in the areas of pollution …

Metallothionein protein evolution: a miniassay

M Capdevila, S Atrian - JBIC Journal of Biological Inorganic Chemistry, 2011 - Springer
Metallothionein (MT) evolution is one of the most obscure yet fascinating aspects of the
study of these atypical metal-binding peptides. The different members of the extremely …

Toxicity of ZnO and CuO nanoparticles to ciliated protozoa Tetrahymena thermophila

M Mortimer, K Kasemets, A Kahru - Toxicology, 2010 - Elsevier
The toxic effects of nanoparticles (NPs) of ZnO and CuO to particle-ingesting model
organism protozoa Tetrahymena thermophila were evaluated. Nano-ZnO was remarkably …

State-of-the-art of metallothioneins at the beginning of the 21st century

M Capdevila, R Bofill, O Palacios, S Atrian - Coordination Chemistry …, 2012 - Elsevier
Metallothioneins (MTs) are a particular type of small metalloprotein that possess a significant
amount of Cys residues, which confer upon them an extraordinary capacity for heavy metal …

Synthetic biology for microbial heavy metal biosensors

HJ Kim, H Jeong, SJ Lee - Analytical and bioanalytical chemistry, 2018 - Springer
Using recombinant DNA technology, various whole-cell biosensors have been developed
for detection of environmental pollutants, including heavy metal ions. Whole-cell biosensors …

[HTML][HTML] Heavy metal whole-cell biosensors using eukaryotic microorganisms: an updated critical review

JC Gutiérrez, F Amaro, A Martín-González - Frontiers in microbiology, 2015 - frontiersin.org
This review analyzes the advantages and disadvantages of using eukaryotic
microorganisms to design whole-cell biosensors (WCBs) for monitoring environmental …

Diversity, structure and regulation of microbial metallothionein: metal resistance and possible applications in sequestration of toxic metals

S Chatterjee, S Kumari, S Rath, M Priyadarshanee… - Metallomics, 2020 - academic.oup.com
Metallothioneins (MTs) are a group of cysteine-rich, universal, low molecular weight proteins
distributed widely in almost all major taxonomic groups ranging from tiny microbes to highly …

[HTML][HTML] A Tetrahymena Piwi bound to mature tRNA 3′ fragments activates the exonuclease Xrn2 for RNA processing in the nucleus

MT Couvillion, G Bounova, E Purdom, TP Speed… - Molecular cell, 2012 - cell.com
Emerging evidence suggests that Argonaute (Ago)/Piwi proteins have diverse functions in
the nucleus and cytoplasm, but the molecular mechanisms employed in the nucleus remain …

Whole‐cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila

F Amaro, AP Turkewitz… - Microbial …, 2011 - Wiley Online Library
Heavy metals are among the most serious pollutants, and thus there is a need to develop
sensitive and rapid biomonitoring methods for heavy metals in the environment. Critical …

[HTML][HTML] Quantitative proteomic analyses of a Pb-adapted Tetrahymena thermophila strain reveal the cellular strategy to Pb (II) stress including lead biomineralization …

P de Francisco, F Amaro, A Martín-González… - Science of the Total …, 2023 - Elsevier
A strain of the protozoan ciliate Tetrahymena thermophila adapted to increasing Pb (II)
concentrations over two years has shown that one of the resistance mechanisms to this …