The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Ubiquitylation? the conjugation of proteins with a small protein called ubiquitin? touches
upon all aspects of eukaryotic biology, and its defective regulation is manifest in diseases …

Loss of p53 function occurs during the development of most, if not all, tumour types. This
paves the way for genomic instability, tumour-associated changes in metabolism …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Genetic lesions that disable key regulators of G1 phase progression in mammalian cells are
present in most human cancers. Mitogen-dependent, cyclin D-dependent kinases (cdk4 and …

The HDM2 protein plays an important role in regulating the stability and function of the p53
tumor suppressor protein. In this report, we show that the ribosomal protein L11 can interact …

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress,
is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing …

Mutations in the TP53 gene are a feature of 50% of all reported cancer cases. In the other
50% of cases, the TP53 gene itself is not mutated but the p53 pathway is often partially …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

To determine whether cellular aging leads to a cardiomyopathy and heart failure, markers of
cellular senescence, cell death, telomerase activity, telomere integrity, and cell regeneration …