Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Chitin, the second most abundant polysaccharide in nature after cellulose, is found in the
exoskeleton of insects, fungi, yeast, and algae, and in the internal structures of other …

Mesenchymal stem cells from corneal stromal stem cells (CSSC) prevent fibrotic scarring
and stimulate regeneration of transparent stromal tissue after corneal wounding in mice …

Abstract YKL-40, a chitinase-3-like protein 1 (CHI3L1) or human cartilage glycoprotein 39
(HC gp-39), is expressed and secreted by various cell-types including macrophages …

Identification and treatment of abdominal aortic aneurysm (AAA) remain among the most
prominent challenges in vascular medicine. MicroRNAs (miRNAs) are crucial regulators of …

In a search of new bone proteins, the glycoprotein YKL-40 was identified in 1989 to be
secreted in vitro in large amount by the human osteosarcoma cell line MG63. The protein …

Abstract Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the
conversion to clinically definite multiple sclerosis in patients with clinically isolated …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

YKL-40, a member of the “mammalian chitinase–like proteins,” is expressed and secreted by
several types of solid tumors. The exact function of YKL-40 in cancer diseases is unknown …