Tuning neural circuits and behaviors by microglia in the adult brain

S Zhao, AD Umpierre, LJ Wu - Trends in neurosciences, 2024 - cell.com
Microglia are the primary immune cells of the CNS, contributing to both inflammatory
damage and tissue repair in neurological disorder. In addition, emerging evidence …

[HTML][HTML] The role of locus coeruleus neuroimmune signaling in the response to social stress in female rats

CE Smiley, BS Pate, SJ Bouknight, EN Harrington… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Neuropsychiatric disorders that result from stress exposure, including post-traumatic stress
disorder and substance abuse, are highly associated with central inflammation. Our …

DREADD Microglia? Targeted Microglial Gi Activation in the Acute Phase can Reduce Seizure Severity, but is Detrimental in the Long Term

LG Bodea, K Borges - Epilepsy Currents, 2024 - journals.sagepub.com
Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures Aastha Dheer,
Dale B Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi …

Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization

S Zhao, L Wang, Y Liang, J Zheng, AD Umpierre… - bioRxiv, 2024 - biorxiv.org
Microglia actively survey the brain and dynamically interact with neurons to maintain brain
homeostasis. Microglial Gi-protein coupled receptors (Gi-GPCRs) play a critical role in …