Increasing evidence suggests that migraine may be the result of an impaired brain glucose
metabolism. Several studies have reported brain mitochondrial dysfunction, impaired brain …

In everyday clinical practice, healthcare professionals often meet chronic pain patients with
a poor nutritional status. A poor nutritional status such as malnutrition, unhealthy dietary …

Mitochondria, the 'powerhouse'of eukaryotic cells, play a key role in cellular homeostasis.
However, defective mitochondria increase mitochondrial ROS (mtROS) production and cell …

BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a
mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular …

Metformin is a hypoglycemic drug widely used in the treatment of type 2 diabetes. It has
been proven to have analgesic and neuroprotective effects. Metformin can reverse pain in …

Polycystic ovary syndrome (PCOS) is the most common reproductive disease affecting the
hormone and metabolic status of women. Its associated symptoms are diverse among the …

Background Emerging evidence showed metformin may have pleiotropic effects on
ameliorating depression. However, whether metformin was associated with decreased risk …

Nanotechnology plays an integral role in multimodal analgesia. In this study, we co-
encapsulated metformin (Met) and curcumin (Cur) into chitosan/alginate (CTS/ALG) …

Chronic pain is a common public health problem and remains an unmet medical need.
Currently available analgesics usually have limited efficacy for the treatment of chronic pain …

Chemotherapy-induced neuropathic pain is a major clinical problem with limited treatment
options. Here, we show that metformin relieves bortezomib (BTZ)-evoked induction and …