Contribution of rat insular cortex to stimulus-guided action

Y Tensaouti, L Morel, SL Parkes - Journal of Neuroscience, 2025 - jneurosci.org
Anticipating rewards is fundamental for decision-making. Animals often use cues to assess
reward availability and to make predictions about future outcomes. The gustatory region of …

A large-scale c-Fos brain mapping study on extinction of cocaine-primed reinstatement

M Lenoir, M Engeln, S Navailles, P Girardeau… - …, 2024 - nature.com
Individuals with cocaine addiction can experience many craving episodes and subsequent
relapses, which represents the main obstacle to recovery. Craving is often favored when …

Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats

MS McGregor, CV Cosme, RT LaLumiere - Neuropsychopharmacology, 2024 - nature.com
Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes
cued reinstatement of cocaine seeking after extinction in rats. It is unknown whether these …

The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference

A Agoitia, A Cruz-Sanchez, I Balderas… - …, 2024 - Springer
Rationale Relapse into substance use is often triggered by exposure to drug-related
environmental cues. The magnitude of drug seeking depends on the duration of abstinence …

D1-Like and D2-Like Dopamine Receptors in the Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits

LM Birioukova, G Van Luijtelaar, IS Midzyanovskaya - Receptors, 2024 - mdpi.com
The involvement of the prefrontal cortical dopaminergic system in the psychopathology of
epilepsies and comorbid conditions such as autism spectrum disorder (ASD) still needs to …

Reward Circuit Local Field Potential Modulations Precede Risk Taking

NC Hughes, H Qian, M Zargari, Z Zhao, B Singh… - bioRxiv, 2024 - biorxiv.org
Risk taking behavior is a symptom of multiple neuropsychiatric disorders and often lacks
effective treatments. Reward circuitry regions including the amygdala, orbitofrontal cortex …