Phase 3 trial of gilteritinib plus azacitidine vs azacitidine for newly diagnosed FLT3mut+ AML ineligible for intensive chemotherapy
ES Wang, P Montesinos, MD Minden… - Blood, The Journal …, 2022 - ashpublications.org
Abstract Treatment results for patients with newly diagnosed FMS-like tyrosine kinase 3
(FLT3)-mutated (FLT3 mut+) acute myeloid leukemia (AML) ineligible for intensive …
(FLT3)-mutated (FLT3 mut+) acute myeloid leukemia (AML) ineligible for intensive …
FLT3 inhibition: a moving and evolving target in acute myeloid leukaemia
Internal tandem duplication (ITD) of the fms-like tyrosine kinase 3 (FLT3) gene is a gain-of-
function mutation common in acute myeloid leukaemia (AML). It is associated with inferior …
function mutation common in acute myeloid leukaemia (AML). It is associated with inferior …
Trisomy 8 as the sole chromosomal aberration in acute myeloid leukemia and myelodysplastic syndromes
K Paulsson, B Johansson - Pathologie Biologie, 2007 - Elsevier
Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid
leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and …
leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and …
Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients
U Bacher, C Haferlach, W Kern… - Blood, The Journal …, 2008 - ashpublications.org
We characterized the mutational status of the FLT3 tyrosine kinase domain (FLT3-TLD) in
3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of …
3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of …
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis
Two distinct forms of fms-like tyrosine kinase (FLT3) gene aberrations, internal tandem
duplication (ITD) and tyrosine kinase domain (TKD) mutations, have been recognized in a …
duplication (ITD) and tyrosine kinase domain (TKD) mutations, have been recognized in a …
FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal …
SP Whitman, AS Ruppert… - Blood, The Journal …, 2008 - ashpublications.org
The prognostic relevance of FLT3 D835/I836 mutations (FLT3-TKD) in cytogenetically
normal acute myeloid leukemia (CN-AML) remains to be established. After excluding …
normal acute myeloid leukemia (CN-AML) remains to be established. After excluding …
A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
We present an analysis of prognostic factors derived from a trial in patients with acute
myeloid leukemia older than 60 years. The AML96 trial included 909 patients with a median …
myeloid leukemia older than 60 years. The AML96 trial included 909 patients with a median …
[HTML][HTML] Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older
VV Prassek, M Rothenberg-Thurley, MC Sauerland… - …, 2018 - ncbi.nlm.nih.gov
A cute myeloid leukemia is a disease of the elderly (median age at diagnosis, 65–70 years).
The prognosis of older acute myeloid leukemia patients is generally poor. While genetic …
The prognosis of older acute myeloid leukemia patients is generally poor. While genetic …
Prognostic value of FLT3 mutations among different cytogenetic subgroups in acute myeloid leukemia
BACKGROUND: The impact of FMS‐like tyrosine kinase 3 (FLT3) mutations and mutation
burden among cytogenetic subgroups of patients with acute myeloid leukemia (AML) other …
burden among cytogenetic subgroups of patients with acute myeloid leukemia (AML) other …
Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group
C Callens, S Chevret, JM Cayuela, B Cassinat… - Leukemia, 2005 - nature.com
Internal tandem duplications (ITDs) of the FLT3 gene have been observed in about 35% of
APL cases. If FLT3-ITD is associated with a worse outcome in patients with acute myeloid …
APL cases. If FLT3-ITD is associated with a worse outcome in patients with acute myeloid …