Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA
genome. The highly conserved frameshift stimulation element (FSE), required for balanced …

Single particle analysis cryo-electron microscopy (EM) and molecular dynamics (MD) have
been complimentary methods since cryo-EM was first applied to the field of structural …

Cryo-electron microscopy (cryo-EM) has become a leading approach for protein structure
determination, but it remains challenging to accurately model atomic structures with cryo-EM …

Cryo-electron microscopy (cryo-EM) has now become a widely used technique for structure
determination of macromolecular complexes. For modeling molecular structures from …

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent
oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how …

Centrioles are microtubule-based organelles required for the formation of centrosomes and
cilia. Centriolar microtubules, unlike their cytosolic counterparts, are stable and grow very …

Drug discovery campaigns against Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) are beginning to target the viral RNA genome,. The frameshift stimulation …

Single-particle cryogenic electron microscopy (cryo-EM) has revolutionized the field of the
structural biology, providing an access to the atomic resolution structures of large …

Over a century ago, physicists started broadly relying on theoretical models to guide new
experiments. Soon thereafter, chemists began doing the same. Now, biological research …

Spirochete bacteria, including important pathogens, exhibit a distinctive means of swimming
via undulations of the entire cell. Motility is powered by the rotation of supercoiled' …