Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent …

The changing landscape of motor neuron disease imaging: the... : Current Opinion in
Neurology The changing landscape of motor neuron disease imaging: the transition from …

Sporadic amyotrophic lateral sclerosis (sALS) is the majority of ALS, and the lack of
appropriate disease models has hindered its research. Induced pluripotent stem cell (iPSC) …

Background Respiratory complications resulting from motor neurons degeneration are the
primary cause of death in amyotrophic lateral sclerosis (ALS). Predicting the need for non …

Objective: The heterogeneity of amyotrophic lateral sclerosis (ALS) survival duration, which
varies from< 1 year to> 10 years, challenges clinical decisions and trials. Utilizing data from …

Objective Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The
assessment of gray matter and white matter cervical spinal cord atrophy across clinical …

Background Motor capacity is crucial in amyotrophic lateral sclerosis (ALS) clinical trial
design and patient care. However, few studies have explored the potential of multimodal …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …