Sepsis: Something old, something new, and a systems view
Sepsis is a clinical syndrome characterized by a multisystem response to a microbial
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
pathogenic insult consisting of a mosaic of interconnected biochemical, cellular, and organ …
The acute inflammatory response in trauma/hemorrhage and traumatic brain injury: current state and emerging prospects
Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
result in death. Inflammation describes a coordinated series of molecular, cellular, tissue …
Insights into the role of chemokines, damage-associated molecular patterns, and lymphocyte-derived mediators from computational models of trauma-induced …
Significance: Traumatic injury elicits a complex, dynamic, multidimensional inflammatory
response that is intertwined with complications such as multiple organ dysfunction and …
response that is intertwined with complications such as multiple organ dysfunction and …
Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation
S Nagaraja, A Wallqvist, J Reifman… - The Journal of …, 2014 - journals.aai.org
Chronic inflammation is rapidly becoming recognized as a key contributor to numerous
pathologies. Despite detailed investigations, understanding of the molecular mechanisms …
pathologies. Despite detailed investigations, understanding of the molecular mechanisms …
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks
Q Mi, G Constantine, C Ziraldo, A Solovyev, A Torres… - PloS one, 2011 - journals.plos.org
Background Complex biological processes such as acute inflammation induced by
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …
trauma/hemorrhagic shock/(T/HS) are dynamic and multi-dimensional. We utilized …
Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
The translation of in vitro findings to clinical outcomes is often elusive. Trauma/hemorrhagic
shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in …
shock (T/HS) results in hepatic hypoxia that drives inflammation. We hypothesize that in …
Toward a model-free feedback control synthesis for treating acute inflammation
An effective and patient-specific feedback control synthesis for inflammation resolution is still
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …
an ongoing research area. A strategy consisting of manipulating a pro and anti-inflammatory …
Trauma in silico: individual-specific mathematical models and virtual clinical populations
Trauma-induced critical illness is driven by acute inflammation, and elevated systemic
interleukin-6 (IL-6) after trauma is a biomarker of adverse outcomes. We constructed a …
interleukin-6 (IL-6) after trauma is a biomarker of adverse outcomes. We constructed a …
Translational systems approaches to the biology of inflammation and healing
Y Vodovotz, G Constantine, J Faeder, Q Mi… - …, 2010 - Taylor & Francis
Inflammation is a complex, non-linear process central to many of the diseases that affect
both developed and emerging nations. A systems-based understanding of inflammation …
both developed and emerging nations. A systems-based understanding of inflammation …
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine
G Nieman, D Brown, J Sarkar, B Kubiak… - Critical care …, 2012 - journals.lww.com
Objective: To gain insights into individual variations in acute inflammation and physiology.
Design: Large-animal study combined with mathematical modeling. Setting: Academic large …
Design: Large-animal study combined with mathematical modeling. Setting: Academic large …