Potential applications of plant biotechnology against SARS-CoV-2

T Capell, RM Twyman, V Armario-Najera, JKC Ma… - Trends in plant …, 2020 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus
responsible for an ongoing human pandemic (COVID-19). There is a massive international …

Molecular farming–the slope of enlightenment

R Fischer, JF Buyel - Biotechnology advances, 2020 - Elsevier
Molecular farming can be defined as the use of plants to produce recombinant protein
products. The technology is now> 30 years old. The early promise of molecular farming was …

Expression of recombinant antibodies

A Frenzel, M Hust, T Schirrmann - Frontiers in immunology, 2013 - frontiersin.org
Recombinant antibodies are highly specific detection probes in research, diagnostics, and
have emerged over the last two decades as the fastest growing class of therapeutic proteins …

Regulatory approval and a first‐in‐human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

JKC Ma, J Drossard, D Lewis, F Altmann… - Plant biotechnology …, 2015 - Wiley Online Library
Although plant biotechnology has been widely investigated for the production of clinical‐
grade monoclonal antibodies, no antibody products derived from transgenic plants have yet …

Plant‐specific glycosylation patterns in the context of therapeutic protein production

V Gomord, AC Fitchette… - Plant biotechnology …, 2010 - Wiley Online Library
While N‐glycan synthesis in the endoplasmic reticulum (ER) is relatively well conserved in
eukaryotes, N‐glycan processing and O‐glycan biosynthesis in the Golgi apparatus are …

Advances in plant molecular farming

OO Obembe, JO Popoola, S Leelavathi… - Biotechnology advances, 2011 - Elsevier
Plant molecular farming (PMF) is a new branch of plant biotechnology, where plants are
engineered to produce recombinant pharmaceutical and industrial proteins in large …

Plant molecular farming: much more than medicines

M Tschofen, D Knopp, E Hood… - Annual Review of …, 2016 - annualreviews.org
Plants have emerged as commercially relevant production systems for pharmaceutical and
nonpharmaceutical products. Currently, the commercially available nonpharmaceutical …

Extremely high-level and rapid transient protein production in plants without the use of viral replication

F Sainsbury, GP Lomonossoff - Plant physiology, 2008 - academic.oup.com
Plant-based overexpression of heterologous proteins has attracted much interest and
development in recent years. To date, the most efficient vectors have been based on RNA …

Heritable genomic fragment deletions and small indels in the putative ENGase gene induced by CRISPR/Cas9 in barley

E Kapusi, M Corcuera-Gómez, S Melnik… - Frontiers in plant …, 2017 - frontiersin.org
Targeted genome editing with the CRISPR/Cas9 system has been used extensively for the
selective mutation of plant genes. Here we used CRISPR/Cas9 to disrupt the putative barley …

Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond

V Yusibov, SJ Streatfield, N Kushnir - Human vaccines, 2011 - Taylor & Francis
In the last few years, plants have become an increasingly attractive platform for recombinant
protein production. This builds on two decades of research, starting with transgenic …