Sirtuins: promising therapeutic targets to treat ischemic stroke

Y Liu, L Wang, G Yang, X Chi, X Liang, Y Zhang - Biomolecules, 2023 - mdpi.com
Stroke is a major cause of mortality and disability globally, with ischemic stroke (IS)
accounting for over 80% of all stroke cases. The pathological process of IS involves …

Neuroprotection by transcranial direct current stimulation in rodent models of focal ischemic stroke: a meta-analysis

J Huang, K Zhao, Z Zhao, Y Qu - Frontiers in Neuroscience, 2021 - frontiersin.org
Infarct size is associated with stroke severity in clinical studies, so reducing it has become an
important target and research hotspot in the treatment of ischemic stroke. Some preclinical …

Transcranial Direct-Current Stimulation Regulates MCT1-PPA-PTEN-LONP1 Signaling to Confer Neuroprotection After Rat Cerebral Ischemia–Reperfusion Injury

X Kong, W Hu, Y Cui, J Gao, X Yao, J Ren, T Lin… - Molecular …, 2022 - Springer
Propionic acid (PPA) is a critical metabolite involved in microbial fermentation, which
functions to reduce fat production, inhibit inflammation, and reduce serum cholesterol levels …

Surfeit Locus Protein 4 as a Novel Target for Therapeutic Intervention in Cerebral Ischemia–Reperfusion Injury

W Hu, X Kong, Y Cui, H Wang, J Gao, X Wang… - Molecular …, 2024 - Springer
Abstract Surfeit locus protein 4 (SURF4) functions as a cargo receptor that is capable of
transporting newly formed proteins from the lumen of the endoplasmic reticulum into …

Non-invasive brain stimulation for functional recovery in animal models of stroke: A systematic review

A Rodriguez, L Amaya-Pascasio… - Neuroscience & …, 2023 - Elsevier
Motor and cognitive dysfunction occur frequently after stroke, severely affecting a patient´ s
quality of life. Recently, non-invasive brain stimulation (NIBS) has emerged as a promising …

Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways

J Cheng, H Yu, ZF Zhang, HX Jiang, P Wu… - Journal of Materials …, 2024 - Springer
Studies have shown that the inhibition of phosphatase and tensin homolog deleted on
chromosome 10 (PTEN) was neuroprotective against ischemia/reperfusion (I/R) injury …

The neuroprotective effects of transcranial direct current stimulation on global cerebral ischemia and reperfusion via modulating apoptotic pathways

R Kaviannejad, SM Karimian, E Riahi, G Ashabi - Brain research bulletin, 2022 - Elsevier
Background Cerebral ischemia-reperfusion, subsequent hyperthermia, and hyperglycemia
lead to neural damage. This study aimed to investigate the effects of using cathodal and/or …

The Relevance of Reperfusion Stroke Therapy for miR-9-3p and miR-9-5p Expression in Acute Stroke—A Preliminary Study

D Gendosz de Carrillo, O Kocikowska, M Rak… - International Journal of …, 2024 - mdpi.com
Reperfusion stroke therapy is a modern treatment that involves thrombolysis and the
mechanical removal of thrombus from the extracranial and/or cerebral arteries, thereby …

Cathodal bilateral transcranial direct‐current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury

H Wang, W Ma, W Hu, X Li, N Shen, Z Li… - The Journal of …, 2024 - Wiley Online Library
Non‐invasive transcranial direct‐current stimulation (tDCS) is a safe ischaemic stroke
therapy. Cathodal bilateral tDCS (BtDCS) is a modified tDCS approach established by us …

Upregulation of mitochondrial PGK1 by ROS-TBC1D15 pathway promotes neuronal death after oxygen-glucose deprivation/reoxygenation injury

S Chen, H Wang, J Chen, J Cheng, J Gao, S Chen… - Brain Research, 2024 - Elsevier
Abstract Phosphoglycerate kinase 1 (PGK1) is extensively located in the cytosol and
mitochondria. The role of PGK1 in ischemic neuronal injury remains elusive. In the in vitro …