A comparison of the different animal models of fetal alcohol spectrum disorders and their use in studying complex behaviors

AR Patten, CJ Fontaine, BR Christie - Frontiers in pediatrics, 2014 - frontiersin.org
Prenatal ethanol exposure (PNEE) has been linked to widespread impairments in brain
structure and function. There are a number of animal models that are used to study the …

The laboratory domestication of Caenorhabditis elegans

MG Sterken, LB Snoek, JE Kammenga, EC Andersen - Trends in Genetics, 2015 - cell.com
Model organisms are of great importance to our understanding of basic biology and to
making advances in biomedical research. However, the influence of laboratory cultivation on …

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans

EZ Macosko, N Pokala, EH Feinberg, SH Chalasani… - Nature, 2009 - nature.com
Innate social behaviours emerge from neuronal circuits that interpret sensory information on
the basis of an individual's own genotype, sex and experience. The regulated aggregation …

Recombinational Landscape and Population Genomics of Caenorhabditis elegans

MV Rockman, L Kruglyak - PLoS genetics, 2009 - journals.plos.org
Recombination rate and linkage disequilibrium, the latter a function of population genomic
processes, are the critical parameters for mapping by linkage and association, and their …

[HTML][HTML] Peptide neuromodulation in invertebrate model systems

PH Taghert, MN Nitabach - Neuron, 2012 - cell.com
Neuropeptides modulate neural circuits controlling adaptive animal behaviors and
physiological processes, such as feeding/metabolism, reproductive behaviors, circadian …

[HTML][HTML] Neuropeptides

C Li, K Kim - WormBook: the online review of C. elegans biology, 2008 - ncbi.nlm.nih.gov
Neuropeptides are short sequences of amino acids that function either directly or indirectly
to modulate synaptic activity. In addition, neuropeptides may also function as primary …

Sexual Deprivation Increases Ethanol Intake in Drosophila

G Shohat-Ophir, KR Kaun, R Azanchi, H Mohammed… - Science, 2012 - science.org
The brain's reward systems reinforce behaviors required for species survival, including sex,
food consumption, and social interaction. Drugs of abuse co-opt these neural pathways …

A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology

EC Andersen, JS Bloom, JP Gerke, L Kruglyak - PLoS genetics, 2014 - journals.plos.org
The mechanistic basis for how genetic variants cause differences in phenotypic traits is often
elusive. We identified a quantitative trait locus in Caenorhabditis elegans that affects three …

Neuropeptide GPCRs in C. elegans

L Frooninckx, L Van Rompay, L Temmerman… - Frontiers in …, 2012 - frontiersin.org
Like most organisms, the nematode Caenorhabditis elegans relies heavily on
neuropeptidergic signaling. This tiny animal represents a suitable model system to study …

Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity

T Wen, CA Parrish, D Xu, Q Wu… - Proceedings of the …, 2005 - National Acad Sciences
Alcohol is likely to affect neurons nonselectively, and the understanding of its action in the
CNS requires elucidation of underlying neuronal circuits and associated cellular processes …