Background: A major challenge in providing mental health interventions for young people is
making such interventions accessible and appealing to those most in need. Online and app …

Background: There is a huge gap in the treatment of mental disorders in Latin America,
especially among socioeconomically disadvantaged groups. Given the sharp increase in …

Objective: To understand the role of depressive symptoms in preclinical Alzheimer's
disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in …

Neuroimaging studies have shown that, despite the abstractness of music, it may mimic
biologically rewarding stimuli (eg, food) in its ability to engage the brain's reward circuitry …

Indolamines are tryptophan-derived specialized metabolites belonging to the huge and
ubiquitous indole alkaloids group. Serotonin and melatonin are the best-characterized …

Background: Suicide is one of the most frequent causes of death in young people
worldwide. Depression lies at the root of this issue, a condition that has a significant …

Objective Deep brain stimulation (DBS) has been used as a treatment of last resort for
treatment-resistant depression (TRD) for more than a decade. Many DBS targets have been …

The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus.
The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate …

Cortical regions such as the orbitofrontal cortex involved in reward and in non-reward and
which are implicated in depression, and the amygdala, are connected to the habenula via …

According to our model of the regulation of appetitive-searching vs. distress-avoiding
behaviors, the motivation to display these essential conducts is regulated by two parallel …