[HTML][HTML] Thiazole ring—A biologically active scaffold
A Petrou, M Fesatidou, A Geronikaki - Molecules, 2021 - mdpi.com
Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …
applications. Its derivatives have a wide range of biological activities such as antioxidant …
[HTML][HTML] Physiological and pathological roles of aldose reductase
M Singh, A Kapoor, A Bhatnagar - Metabolites, 2021 - mdpi.com
Aldose reductase (AR) is an aldo-keto reductase that catalyzes the first step in the polyol
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
pathway which converts glucose to sorbitol. Under normal glucose homeostasis the pathway …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
[HTML][HTML] Aldose reductase: an emerging target for development of interventions for diabetic cardiovascular complications
S Jannapureddy, M Sharma, G Yepuri… - Frontiers in …, 2021 - frontiersin.org
Diabetes is a leading cause of cardiovascular morbidity and mortality. Despite numerous
treatments for cardiovascular disease (CVD), for patients with diabetes, these therapies …
treatments for cardiovascular disease (CVD), for patients with diabetes, these therapies …
Synthesis, biological evaluation, and in silico study of novel library sulfonates containing quinazolin‐4(3H)‐one derivatives as potential aldose reductase inhibitors
A series of novel sulfonates containing quinazolin‐4 (3 H)‐one ring derivatives was
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
designed to inhibit aldose reductase (ALR2, EC 1.1. 1.21). Novel quinazolinone derivatives …
Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus
Quinazolinones, which represent an important part of nitrogen‐containing six‐membered
heterocyclic compounds, are frequently used in drug design due to their wide biological …
heterocyclic compounds, are frequently used in drug design due to their wide biological …
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Abstract Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
Isolation of Some Phenolic Compounds from Plantago subulata L. and Determination of Their Antidiabetic, Anticholinesterase, Antiepileptic and Antioxidant Activity
In the current study, some phenolic compounds, including acteoside, isoacteoside,
echinacoside, and arenarioside purified and characterized from Plantago subulata. These …
echinacoside, and arenarioside purified and characterized from Plantago subulata. These …
Novel acetic acid derivatives containing quinazolin‐4(3H)‐one ring: Synthesis, in vitro, and in silico evaluation of potent aldose reductase inhibitors
Aldose reductase (AR) is a crucial enzyme of the polyol pathway through which glucose is
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
metabolized under conditions of hyperglycemia related to diabetes. A series of novel acetic …
Synthesis and characterization of novel acyl hydrazones derived from vanillin as potential aldose reductase inhibitors
In the polyol pathway, aldose reductase (AR) catalyzes the formation of sorbitol from
glucose. In order to detoxify some dangerous aldehydes, AR is essential. However, due to …
glucose. In order to detoxify some dangerous aldehydes, AR is essential. However, due to …