The major histocompatibility complex (MHC) loci are amongst the most polymorphic regions
in the genomes of vertebrates. In the human population, thousands of MHC gene variants …

Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent
on the identification of cell surface MHC molecules bearing peptides generated from either …

Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide
loading complex plays a critical role in antigen presentation and immune recognition …

Major histocompatibility complex class I (MHC I) molecules are central to adaptive immunity.
Their assembly, epitope selection, and antigen presentation are controlled by the MHC I …

Immunological chaperones tapasin and TAP binding protein, related (TAPBPR) play key
roles in antigenic peptide optimization and quality control of nascent class I major …

Adaptive immunity depends on cell surface presentation of antigenic peptides by major
histocompatibility complex class I (MHC I) molecules and on stringent ER quality control in …

Chaperones tapasin and transporter associated with antigen processing (TAP)-binding
protein related (TAPBPR) associate with the major histocompatibility complex (MHC)-related …

How the genetic landscape governs a tumor's response to immunotherapy remains poorly
understood. To assess the immune-modulatory capabilities of 573 genes associated with …

The repertoire of peptides presented by major histocompatibility complex class I (MHC-I)
molecules on the cell surface is tailored by the ER-resident peptide loading complex (PLC) …

The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein
complexes encompassing tumor neoantigens provide a rationale for target selection …