Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

At least 14 different carbonic anhydrase (CA, EC 4.2. 1.1) isoforms were isolated in higher
vertebrates, where these zinc enzymes play crucial physiological roles. Some of these …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

By optimizing binding to a selected target protein, modern drug research strives to develop
safe and efficacious agents for the treatment of disease. Selective drug action is intended to …

Molecules containing the sulfonamide group (R-SO2NH2) as well as its structurally related
isosters, sulfamido (R-NH-SO2NH2) and sulfamato (RO-SO2NH2), constitute the most …

E7070 [N-(3-chloro-7-indolyl)-1, 4-benzenedisulfonamide] is an anticancer drug candidate
under clinical development for the treatment of several types of cancers. We prove here that …

Inhibitors and activators of the zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1) have a
large number of applications in therapy. Many types of such new derivatives have been …

Starting from the very simple molecule sulfamic acid, O‐substituted‐, N‐substituted‐, or di‐
/tri‐substituted sulfamates may be obtained, which show specific biological activities which …

A series of sugar sulfamate/sulfamide derivatives were prepared and assayed as inhibitors
of three carbonic anhydrase (CA) isozymes, hCA I, hCA II and bCA IV. Best inhibitory …