Developing effective drugs for Alzheimer's disease (AD), the most common cause of
dementia, has been difficult because of complicated pathogenesis. Here, we report an …

Many clinical trials for cancer precision medicine have yielded unsatisfactory results due to
challenges such as drug resistance and low efficacy. Drug resistance is often caused by the …

Oscillations are surprisingly common in the immune system, both in its healthy state and in
disease. The most famous example is that of periodic fevers caused by the malaria parasite …

The IκB kinase (IKK)-NF-κB pathway plays a critical role in oncogenesis. Recently, we have
shown that p53 regulates glucose metabolism through the IKK-NF-κB pathway and that, in …

Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an
exquisite example of how cellular signaling pathways can be regulated to produce different …

This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO‐1) in
some situations results in cell death and in others leads to the activation of NF‐κB. We …

Cyclin D1 is frequently overexpressed in hepatocellular carcinoma (HCC) exhibiting
increased malignant phenotypes. It has also been known that the hepatitis Bx (HBx) protein …

Liver cancer is the second leading cause of cancer‑associated death worldwide. The
present study aimed to evaluate the infiltration of M1‑like tumor‑associated macrophages …

Abstract Background The NF-κ B regulatory network controls innate immune response by
transducing variety of pathogen-derived and cytokine stimuli into well defined single-cell …

Cetuximab (CTX), a monoclonal antibody against epidermal growth factor receptor, is being
widely used for colorectal cancer (CRC) with wild‐type (WT) KRAS. However, its …