The immunology of rheumatoid arthritis
CM Weyand, JJ Goronzy - Nature immunology, 2021 - nature.com
The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
production of autoantibodies against post-translationally modified proteins (checkpoint 1) …
Autoimmune diseases—connecting risk alleles with molecular traits of the immune system
M Gutierrez-Arcelus, SS Rich… - Nature Reviews …, 2016 - nature.com
Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure
The host's gene expression and gene regulatory response to pathogen exposure can be
influenced by a combination of the host's genetic background, the type of and exposure time …
influenced by a combination of the host's genetic background, the type of and exposure time …
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
There is increasing evidence that many risk loci found using genome-wide association
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …
Methods and insights from single-cell expression quantitative trait loci
Recent advancements in single-cell technologies have enabled expression quantitative trait
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
locus (eQTL) analysis across many individuals at single-cell resolution. Compared with bulk …
Update on the genetic architecture of rheumatoid arthritis
Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic
loci associated with susceptibility to RA and have refined the RA-association model for HLA …
loci associated with susceptibility to RA and have refined the RA-association model for HLA …
Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci
M Gutierrez-Arcelus, Y Baglaenko, J Arora, S Hannes… - Nature …, 2020 - nature.com
Genetic studies have revealed that autoimmune susceptibility variants are over-represented
in memory CD4+ T cell regulatory elements,–. Understanding how genetic variation affects …
in memory CD4+ T cell regulatory elements,–. Understanding how genetic variation affects …
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases
B Soskic, E Cano-Gamez, DJ Smyth, WC Rowan… - Nature …, 2019 - nature.com
Immune-disease-associated variants are enriched in active chromatin regions of T cells and
macrophages. However, whether these variants function in specific cell states is unknown …
macrophages. However, whether these variants function in specific cell states is unknown …
Genetic basis of autoimmunity
Autoimmune diseases affect up to approximately 10% of the population. While rare
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …
Mendelian autoimmunity syndromes can result from monogenic mutations disrupting …
The importance of differences; On environment and its interactions with genes and immunity in the causation of rheumatoid arthritis
L Klareskog, J Rönnelid, S Saevarsdottir… - Journal of internal …, 2020 - Wiley Online Library
The current review uses rheumatoid arthritis (RA) as a prominent example for how studies
on the interplay between environmental and genetic factors in defined subsets of a disease …
on the interplay between environmental and genetic factors in defined subsets of a disease …