Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

The parabrachial nucleus (PBN) has long been recognized as a sensory relay receiving an
array of interoceptive and exteroceptive inputs relevant to taste and ingestive behavior, pain …

The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature
and touch information from the spinal cord to the brain,,–. Projection neurons of the …

The brain contains both generalized and stimulus-type-specific representations of aversive
events, but models of how these are integrated and related to subjective experience are …

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …

Pain decreases the activity of many ventral tegmental area (VTA) dopamine (DA) neurons,
yet the underlying neural circuitry connecting nociception and the DA system is not …

The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the
amygdala for processing affective responses. However, it is unclear whether the LPBN …

Perception of threats is essential for survival. Previous findings suggest that parallel
pathways independently relay innate threat signals from different sensory modalities to …

Breathing can be heavily influenced by pain or internal emotional states, but the neural
circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …