3′-end processing of eukaryotic mRNA: machinery, regulation, and impact on gene expression
V Boreikaitė, LA Passmore - Annual review of biochemistry, 2023 - annualreviews.org
Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …
transcript. This process is mediated by a number of protein factors that cleave the pre …
NS1: a Key protein in the “game” between influenza A virus and host in innate immunity
Z Ji, X Wang, X Liu - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Since the influenza pandemic occurred in 1918, people have recognized the perniciousness
of this virus. It can cause mild to severe infections in animals and humans worldwide, with …
of this virus. It can cause mild to severe infections in animals and humans worldwide, with …
Transcription and splicing: A two‐way street
RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …
The influenza A virus endoribonuclease PA-X usurps host mRNA processing machinery to limit host gene expression
L Gaucherand, BK Porter, RE Levene, EL Price… - Cell reports, 2019 - cell.com
Many viruses shut off host gene expression to inhibit antiviral responses. Viral proteins and
host proteins required for viral replication are typically spared in this process, but the …
host proteins required for viral replication are typically spared in this process, but the …
The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome
T Krischuns, B Arragain, C Isel, S Paisant… - Nature …, 2024 - nature.com
The current model is that the influenza virus polymerase (FluPol) binds either to host RNA
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …
polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its …
Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
Infection by viruses, including herpes simplex virus-1 (HSV-1), and cellular stresses cause
widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII) in …
widespread disruption of transcription termination (DoTT) of RNA polymerase II (RNAPII) in …
Innate immune response to influenza virus at single-cell resolution in human epithelial cells revealed paracrine induction of interferon lambda 1
Early interactions of influenza A virus (IAV) with respiratory epithelium might determine the
outcome of infection. The study of global cellular innate immune responses often masks …
outcome of infection. The study of global cellular innate immune responses often masks …
[HTML][HTML] Human virus transcriptional regulators
Viral genomes encode transcriptional regulators that alter the expression of viral and host
genes. Despite an emerging role in human diseases, a thorough annotation of human viral …
genes. Despite an emerging role in human diseases, a thorough annotation of human viral …
Unconventional viral gene expression mechanisms as therapeutic targets
Unlike the human genome that comprises mostly noncoding and regulatory sequences,
viruses have evolved under the constraints of maintaining a small genome size while …
viruses have evolved under the constraints of maintaining a small genome size while …
[HTML][HTML] Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms
A Casco, M Ohashi, E Johannsen - Cell reports, 2024 - cell.com
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus associated with multiple cancers
and autoimmune diseases. Unlike most herpesviruses, EBV reactivation from latency occurs …
and autoimmune diseases. Unlike most herpesviruses, EBV reactivation from latency occurs …