Cell membranes interact via anchored receptor and ligand molecules. Central questions on
cell adhesion concern the binding affinity of these membrane-anchored molecules, the …

Using computer simulations, we systematically studied the influence of different design
parameters of a spherical nanoparticle tethered with monovalent ligands on its efficiency of …

Increasing valence can enhance the ability of molecular targeting constructs to bind
specifically to targeted cells for drug delivery. Here, we mathematically model the length and …

Selectivity of interactions between nanoparticles functionalized by tethered ligands and cell
surfaces with different densities of receptors plays an essential role in biorecognition and its …

Using a model system based on electrostatics, we probe interactions between spherical
particles (negative silica) and planar surfaces that present randomly placed discrete …

Using Monte Carlo simulations, we analyze the efficiency in targeting mobile receptors on
cell surfaces by nanoparticles carrying multivalent (divalent, tetravalent) ligands. We show …

Recent experimental and theoretical studies of biomimetic membrane adhesions [Bruinsma
et al., Phys. Rev. E 61, 4253 (2000); Boulbitch et al., Biophys. J. 81, 2743 (2001)] suggested …

According to classical thermodynamics, biological ligand− receptor bonds should have a
median lifetime of about 2 ms, and nearly half should have lifetimes of nanoseconds to …

In this paper, we analyze the thermodynamics of interactions between surfaces mediated by
polymer-tethered ligand-receptor binding. From statistical thermodynamics calculations, we …

The reversible binding between a planar polymer layer functionalized by ligands and a
planar cell surface containing different densities of mobile receptors has been studied by …