Advances in vaccine development for Chlamydia trachomatis

TB Poston - Pathogens and Disease, 2024 - academic.oup.com
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection globally.
Antibiotic treatment is highly effective, but infection is often asymptomatic resulting in most …

[HTML][HTML] Anti-sperm Antibody Positivity in Men with Varicocele: A Systematic Review and Meta-Analysis

M Falcone, K Bocu, H Keskin… - The World Journal …, 2024 - pmc.ncbi.nlm.nih.gov
Purpose Despite the significant role of varicocele in the pathogenesis of male infertility, its
association with anti-sperm antibodies (ASA) remains controversial. This systematic review …

IL-23 receptor signaling licenses group 3-like innate lymphoid cells to restrict a live-attenuated oral Chlamydia vaccine in the gut

Y He, Y Wang, R He, AM Abdelsalam… - Infection and …, 2023 - Am Soc Microbiol
An IFNγ-susceptible mutant of Chlamydia muridarum is attenuated in pathogenicity in the
genital tract and was recently licensed as an intr acellular O ral vaccine v ector or intrOv …

Preclinical screen for protection efficacy of chlamydial antigens that are immunogenic in humans

C Lu, J Wang, G Zhong - Infection and immunity, 2023 - Am Soc Microbiol
To search for subunit vaccine candidates, immunogenic chlamydial antigens identified in
humans were evaluated for protection against both infection and pathology in a mouse …

[HTML][HTML] Stability and antigenicity of Chlamydia muridarum major outer membrane protein antigen at body temperature

FA Russell, L Trim, E Bryan, MA Fisher, D Leahy… - Vaccine, 2024 - Elsevier
Chlamydia is an obligate intracellular bacterial pathogen responsible for disease and
infertility across multiple species. Currently vaccines are being studied to help reduce the …