Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

The female reproductive tract (FRT), similar to other mucosal sites, harbours a site-specific
microbiome, which has an essential role in maintaining health and homeostasis. In the …

Answer questions and earn CME/CNE The human body harbors enormous numbers of
microbiota that influence cancer susceptibility, in part through their prodigious metabolic …

Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been
widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung …

Background Variability in genes implicated in drug pharmacokinetics or drug response can
modulate treatment efficacy or predispose to adverse drug reactions. Besides common …

Systems biology provides an opportunity to discover the role that gut microbiota play in
almost all aspects of human health. Existing evidence supports the hypothesis that gut …

Importance The gut microbiome, home to the vast kingdom of diverse commensal bacteria
and other microorganisms residing within the gut, was once thought to only have roles …

Purpose Intestinal mucositis and diarrhea are common manifestations of anticancer
regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs. These side …

Recently, preclinical and clinical studies targeting several types of cancer strongly supported
the key role of the gut microbiota in the modulation of host response to anti-tumoral …

Irinotecan is an anticancer agent widely used for the treatment of solid tumors, including
colorectal and pancreatic cancers. Severe neutropenia and diarrhea are common dose …