With the ageing population in most countries, disorders of bone and mineral metabolism are
becoming increasingly relevant to every day clinical practice. Consequently, the interest in …

Objectives: An overview of biochemical markers of bone metabolism is presented along with
indications for their clinical utilization. Design and Methods: The structure, cyclical …

Background and Methods Mutations in the estrogen-receptor gene have been thought to be
lethal. A 28-year-old man whose estrogen resistance was caused by a disruptive mutation in …

I. Introduction THERE is increasing awareness among scientists, clinicians, policy makers,
and the general public of the costs and health care problems associated with osteoporosis …

PURPOSE: In contrast to renal and hepatic failure, congestive heart failure (CHF) has not
been associated with a defined metabolic bone disorder. However, low bone mass has …

Collagen is the main source of extracellular support for multicellular animals. The
mechanical strength of collagen fibrils depends on a highly regulated mechanism of …

In this article we review the biochemical basis for markers of bone metabolism and comment
on their bone specificity and representativeness for bone tissue. Major developments have …

Several studies in recent years have shown that the pyridinium crosslinks of collagen
provide good urinary markers of collagen degradation, primarily reflecting bone resorption …

The article presents information on the biochemical, technical and analytical aspects of
molecular markers of bone turnover. Like all chemical analytes, markers of bone turnover …

Objective: The mechanism of bone loss in patients with inflammatory bowel disease (IBD) is
not completely understood. The aim of this study was to assess indices of bone turnover and …