Splicing factors are affected by recurrent somatic mutations and copy number variations in
several types of haematologic and solid malignancies, which is often seen as prima facie …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

Inflammation is strongly associated with pancreatic ductal adenocarcinoma (PDAC), a highly
lethal malignancy. Dysregulated RNA splicing factors have been widely reported in …

Background Both aberrant alternative splicing and m6A methylation play complicated roles
in the development of pancreatic cancer (PC), while the relationship between these two …

The production of noncanonical mRNA transcripts is associated with cell transformation.
Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T …

The ubiquitin-proteasome system (UPS) is an essential protein quality controller for
regulating protein homeostasis and autophagy. Ubiquitination is a protein modification …

Splicing of pre‐mRNA is an essential part of eukaryotic gene expression. Serine‐/arginine‐
rich (SR) proteins are highly conserved RNA‐binding proteins present in all metazoans and …

Dysregulation of alternative splicing in prostate cancer is linked to transcriptional programs
activated by AR, ERG, FOXA1, and MYC. Here, we show that FOXA1 functions as the …

Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid cells that play
an important role in diseases. MDSCs promote Th17 differentiation and aggravate systemic …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …