Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian
and military populations. OP compounds include the nefarious G and V chemical nerve …

Obviously, delivery of the medications to the brain is more difficult than other tissues due to
the existence of a strong obstacle, which is called blood-brain barrier (BBB). Because of the …

Organophosphorus (OP) nerve agents inhibit acetylcholinesterase (AChE), creating a
cholinergic crisis in which death can occur. The phosphylated serine residue spontaneously …

After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents,
a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When …

Acetylcholinesterase (AChE) inhibition by organophosphorus (OP) compounds poses a
serious health risk to humans. While many therapeutics have been tested for treatment after …

For centuries, nations, armies and civilians have used toxic chemicals for nefarious
purposes. Although forbidden from use during warfare, chemical weapons have an …

Chemical warfare agents, especially organophosphorus (OP) compounds, are known for
their extreme toxicity causing inhibition of acetylcholinesterase (AChE) enzyme activity due …

Organophosphates (OP) target the enzyme cholinesterases, and acetylcholinesterase
(AChE) is the key target of OP. phosphorylation of AChE leads to inhibition of AChE, and that …

Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that
cause adverse effects with many biological systems. Development of methods for …

Nerve agents are organophosphates (OPs) that act as potent inhibitors of
acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of acetylcholine …