IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

The update immune-regulatory role of pro-and anti-inflammatory cytokines in recurrent pregnancy losses

X Yang, Y Tian, L Zheng, T Luu… - International journal of …, 2022 - mdpi.com
Recurrent pregnancy losses (RPL) is a common reproductive disorder with various
underlying etiologies. In recent years, rapid progress has been made in exploring the …

Association between Porphyromonas Gingivalis and systemic diseases: Focus on T cells-mediated adaptive immunity

C Li, R Yu, Y Ding - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
The association between periodontal disease and systemic disease has become a research
hotspot. Porphyromonas gingivalis (P. gingivalis), a crucial periodontal pathogen, affects the …

Interleukin-35: expanding its job profile

DV Sawant, K Hamilton, DAA Vignali - Journal of Interferon & …, 2015 - liebertpub.com
Counter-regulation afforded by specialized regulatory cell populations and
immunosuppressive cytokines is critical for balancing immune outcome. The inhibitory …

Porphyromonas gingivalis and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms

A Chopra, R Radhakrishnan… - Critical reviews in …, 2020 - Taylor & Francis
Abstract Porphyromonas gingivalis (P. gingivalis), a Gram-negative facultative anaerobe of
the oral cavity, is associated with the onset of various adverse pregnancy outcomes. P …

Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases

M Jing, X Chen, H Qiu, W He, Y Zhou, D Li… - Frontiers in …, 2023 - frontiersin.org
Trophoblast immune cell interactions are central events in the immune microenvironment at
the maternal-fetal interface. Their abnormalities are potential causes of various pregnancy …

IL‐35, a hallmark of immune‐regulation in cancer progression, chronic infections and inflammatory diseases

M Teymouri, M Pirro, F Fallarino… - … journal of cancer, 2018 - Wiley Online Library
Cytokine members of the IL‐12 family have attracted enormous attention in the last few
years, with IL‐35 being the one of the most attractive‐suppressive cytokine. IL‐35 is an …

Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions

I Henarejos-Castillo, A Devesa-Peiro… - Molecular Human …, 2022 - academic.oup.com
COVID-19 exerts systemic effects that can compromise various organs and systems.
Although retrospective and in silico studies and prospective preliminary analysis have …

Decreased production of TNF-α and IL-6 inflammatory cytokines in non-pregnant idiopathic RPL women immunomodulatory effect of sildenafil citrate on the cellular …

M Kniotek, M Zych, A Roszczyk, M Szafarowska… - Journal of Clinical …, 2021 - mdpi.com
Sildenafil citrate (SC), a PDE5 inhibitor, a drug for erectile dysfunction (ED) and pulmonary
hypertension (PAH), was found to exert a positive effect on pregnancy outcomes when …

Dysregulation of the interleukin-17A pathway in endometrial tissue from women with unexplained infertility affects pregnancy outcome following assisted reproductive …

DA Crosby, LE Glover, EP Brennan, P Kelly… - Human …, 2020 - academic.oup.com
STUDY QUESTION Which transcriptomic alterations in mid-luteal endometrial scratch
biopsies, taken prior to the assisted reproductive treatment (ART) treatment cycle are …