[HTML][HTML] Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Network for network concept offers new insights into host-SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs

N Eskandarzade, A Ghorbani, S Samarfard… - Computers in biology …, 2022 - Elsevier
Abstract SARS-CoV-2, the causal agent of COVID-19, is primarily a pulmonary virus that can
directly or indirectly infect several organs. Despite many studies carried out during the …

Intrinsically disordered proteins: Perspective on COVID-19 infection and drug discovery

R Tenchov, QA Zhou - ACS Infectious Diseases, 2022 - ACS Publications
Since the beginning of the COVID-19 pandemic caused by SARS-CoV-2, millions of patients
have been diagnosed and many of them have died from the disease worldwide. The …

[HTML][HTML] Newly emerged antiviral strategies for SARS-CoV-2: From deciphering viral protein structural function to the development of vaccines, antibodies, and small …

C Zhang, M Yang - International Journal of Molecular Sciences, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) caused by the infection of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has become the most severe health crisis, causing …

[HTML][HTML] Biology of the SARS-CoV-2 Coronavirus

RN Mingaleeva, NA Nigmatulina… - Biochemistry …, 2022 - Springer
New coronavirus infection causing COVID-19, which was first reported in late 2019 in China,
initiated severe social and economic crisis that affected the whole world. High frequency of …

[HTML][HTML] Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm

A Rabiu Abubakar, R Ahmad, AB Rowaiye, S Rahman… - Life, 2022 - mdpi.com
COVID-19-infected patients require an intact immune system to suppress viral replication
and prevent complications. However, the complications of SARS-CoV-2 infection that led to …

A conserved N protein nano‐vaccine of COVID‐19 exerts potent and cross‐reactive humoral and cellular immune responses in mice

B Li, J Zhang, Y Huang, X Li, J Feng… - Journal of Medical …, 2023 - Wiley Online Library
As severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) mutates continually,
the current vaccines are unable to provide sufficient protection. It is important to develop a …

[HTML][HTML] Unveiling the Pathological Mechanisms of Death Induced by SARS-CoV-2 Viral Pneumonia

GC Oprinca, CI Mohor, A Oprinca-Muja, A Hașegan… - Microorganisms, 2024 - mdpi.com
In this comprehensive study of 15 deceased patients with confirmed SARS-CoV-2 infection,
spanning a time frame of 1 to 68 days from confirmation to death, autopsies were …

Exploration of potential inhibitors for SARS‐CoV‐2 Mpro considering its mutants via structure‐based drug design, molecular docking, MD simulations, MM/PBSA, and …

A Ghasemlou, V Uskoković… - Biotechnology and …, 2023 - Wiley Online Library
The main protease (Mpro) of SARS‐COV‐2 plays a vital role in the viral life cycle and
pathogenicity. Due to its specific attributes, this 3‐chymotrypsin like protease can be a …

[HTML][HTML] Characterization of the interaction between SARS-CoV-2 membrane protein (M) and proliferating cell nuclear antigen (PCNA) as a potential therapeutic target

ÉP Zambalde, ICB Pavan, MCS Mancini… - Frontiers in Cellular …, 2022 - frontiersin.org
SARS-CoV-2 is an emerging virus from the Coronaviridae family and is responsible for the
ongoing COVID-19 pandemic. In this work, we explored the previously reported SARS-CoV …