Cardiac fibrosis

NG Frangogiannis - Cardiovascular research, 2021 - academic.oup.com
Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

[HTML][HTML] Transforming growth factor–β in tissue fibrosis

NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially
restricted generation of bioactive TGF-β from latent stores requires the cooperation of …

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

H Khalil, O Kanisicak, V Prasad… - The Journal of …, 2017 - Am Soc Clin Investig
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue
injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …

Therapeutic targets for cardiac fibrosis: from old school to next-gen

JG Travers, CA Tharp, M Rubino… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Cardiac fibrosis: the fibroblast awakens

JG Travers, FA Kamal, J Robbins, KE Yutzey… - Circulation …, 2016 - Am Heart Assoc
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?

M Sweeney, B Corden, SA Cook - EMBO molecular medicine, 2020 - embopress.org
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Connective tissue growth factor (CTGF) from basics to clinics

Y Ramazani, N Knops, MA Elmonem, TQ Nguyen… - Matrix Biology, 2018 - Elsevier
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening

H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

D Vanhoutte, TG Schips, A Vo, KM Grimes… - Nature …, 2021 - nature.com
The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …