NG Frangogiannis - Journal of Experimental Medicine, 2020 - rupress.org
TGF-β is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-β from latent stores requires the cooperation of …
NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases, and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
The master cytokine TGF-β mediates tissue fibrosis associated with inflammation and tissue injury. TGF-β induces fibroblast activation and differentiation into myofibroblasts that secrete …
Cardiovascular diseases remain the leading cause of death worldwide, with pathological fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …
Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …
Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein involved in the control of biological processes, such as cell proliferation, differentiation …
Cardiovascular disease is the leading cause of death worldwide. Although investment in drug discovery and development has been sky-rocketing, the number of approved drugs has …
The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury- induced mediators of cellular attachment dynamics and extracellular matrix protein …