Overview of the composition of whole grains' phenolic acids and dietary fibre and their effect on chronic non-communicable diseases

J Khan, MZ Khan, Y Ma, Y Meng, A Mushtaq… - International journal of …, 2022 - mdpi.com
Chronic non-communicable diseases are the major cause of death globally. Whole grains
are recommended in dietary guidelines worldwide due to increasing evidence that their …

Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity

M Packer - Circulation, 2018 - Am Heart Assoc
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies

ME Casado, R Collado-Pérez, LM Frago… - International Journal of …, 2023 - mdpi.com
Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

Angiogenic endothelial cell signaling in cardiac hypertrophy and heart failure

R Gogiraju, ML Bochenek, K Schäfer - Frontiers in cardiovascular …, 2019 - frontiersin.org
Endothelial cells are, by number, one of the most abundant cell types in the heart and active
players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in …

Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism

L Han, D Huang, S Wu, S Liu, C Wang, Y Sheng… - Nature cell …, 2023 - nature.com
Lipid droplets (LDs) are cellular organelles critical for lipid homeostasis, with intramyocyte
LD accumulation implicated in metabolic disorder-associated heart diseases. Here we …

In vivo rodent models of type 2 diabetes and their usefulness for evaluating flavonoid bioactivity

JY Fang, CH Lin, TH Huang, SY Chuang - Nutrients, 2019 - mdpi.com
About 40% of the world's population is overweight or obese and exist at risk of developing
type 2 diabetes mellitus (T2D). Obesity is a leading pathogenic factor for developing insulin …

Diabetes and cardiovascular disease: inter-relation of risk factors and treatment

A Sharma, S Mittal, R Aggarwal… - Future Journal of …, 2020 - Springer
Background The diabetes mellitus prevalence is still advancing and increasingly becoming
one of the globally most severe and expensive chronic illnesses. The strong correlation …

Role of Leptin in Obesity, Cardiovascular Disease, and Type 2 Diabetes

T Vilariño-García, ML Polonio-González… - International Journal of …, 2024 - mdpi.com
Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in
every 11 adults; among them, 90–95% of cases are type 2 diabetes mellitus. This is partly …

Do sodium‐glucose co‐transporter‐2 inhibitors prevent heart failure with a preserved ejection fraction by counterbalancing the effects of leptin? A novel hypothesis

M Packer - Diabetes, Obesity and Metabolism, 2018 - Wiley Online Library
Sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors reduce the risk of serious heart failure
events in patients with type 2 diabetes, but little is known about mechanisms that might …

Impact of obesity on cardiac metabolism, fibrosis, and function

R Mahajan, DH Lau, P Sanders - Trends in cardiovascular medicine, 2015 - Elsevier
Obesity is a global pandemic with a huge burden on the healthcare system. Obesity is not
only linked to the development of risk factors for atherosclerotic vascular disease but also …