Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from
cells of the cardiovascular system, and are considered important mediators of intercellular …

Abstract siRNA‐mediated management of myocardial ischemia reperfusion (IR) injury is
greatly hampered by the inefficient myocardial enrichment and cardiomyocyte transfection …

Chronic diabetic wounds are primarily caused by infection, inflammation, and angiogenesis-
related disorders. An ideal approach for treating chronic diabetic wounds is by combining …

BACKGROUND: Adeno-associated virus (AAV) has emerged as one of the best tools for
cardiac gene delivery due to its cardiotropism, long-term expression, and safety. However, a …

In recent years, long non-coding RNAs (lncRNAs) have been demonstrated to be associated
with many physiological and pathological processes in cardiac. Recent studies have shown …

Objective MicroRNAs (miRNAs) are essential biomarkers during development of human
diseases. We aimed to explore the role of hypoxia-induced bone marrow mesenchymal …

Novel bio-therapeutic agents that harness the properties of small, non-coding nucleic acids
hold great promise for clinical applications. These include antisense oligonucleotides that …

Highlights•Active targeting uses ligands to target drugs to particular tissues or
cells.•Antibodies are commonly used targeting ligands which are bulky and difficult to …

This virtual workshop was convened by the National Heart, Lung, and Blood Institute, in
partnership with the Office of Strategic Coordination of the Office of the National Institutes of …