The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

[HTML][HTML] Role of microbiota-derived short-chain fatty acids in nervous system disorders

R Mirzaei, B Bouzari, SR Hosseini-Fard… - Biomedicine & …, 2021 - Elsevier
During the past decade, accumulating evidence from the research highlights the suggested
effects of bacterial communities of the human gut microbiota and their metabolites on health …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Molecular mechanisms of brain water transport

N MacAulay - Nature Reviews Neuroscience, 2021 - nature.com
Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

RS Gomolka, LM Hablitz, H Mestre, M Giannetto, T Du… - Elife, 2023 - elifesciences.org
The glymphatic system is a fluid transport network of cerebrospinal fluid (CSF) entering the
brain along arterial perivascular spaces, exchanging with interstitial fluid (ISF), ultimately …

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells

TCW Julia, M Wang, AA Pimenova, KR Bowles… - Stem cell reports, 2017 - cell.com
Growing evidence implicates the importance of glia, particularly astrocytes, in neurological
and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation …

Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
Astrocytes are key homeostatic regulators in the central nervous system and play important
roles in physiology. After brain damage caused by eg, status epilepticus, traumatic brain …

Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain

S Rayaprolu, S Bitarafan, JV Santiago… - Nature …, 2022 - nature.com
Proteomic profiling of brain cell types using isolation-based strategies pose limitations in
resolving cellular phenotypes representative of their native state. We describe a mouse line …

The many faces of astrocytes in Alzheimer's disease

MD Monterey, H Wei, X Wu, JQ Wu - Frontiers in Neurology, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease and is the most
common cause of dementia in an aging population. The majority of research effort has …

The water transport system in astrocytes–Aquaporins

Z Zhou, J Zhan, Q Cai, F Xu, R Chai, K Lam, Z Luan… - Cells, 2022 - mdpi.com
Highlights (AQPs) are transmembrane proteins responsible for fast water movement across
cell membranes, including those of astrocytes. The expression and subcellular localization …