Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …

Inherited platelet disorders resulting from platelet function defects and a normal platelet
count cause a moderate or severe bleeding diathesis. Since the description of Glanzmann …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is …

Background Severe COVID-19 is associated with marked endothelial cell (EC) activation
that plays a key role in immunothrombosis and pulmonary microvascular occlusion …

Hermansky–Pudlak syndrome (HPS) is characterized by defects of multiple tissue‐specific
lysosome‐related organelles (LROs), typically manifesting with oculocutaneous albinism or …

Abstract von Willebrand factor (VWF) is an essential hemostatic protein that is synthesized
and secreted by endothelial cells and stored in Weibel-Palade bodies (WPBs). The …

Platelet activation induces the secretion of proteins that promote platelet aggregation and
inflammation. However, detailed analysis of the released platelet proteome is hampered by …

The Weibel–Palade body (WPB) is one of the lysosome-related organelles (LROs) in
endothelial cells, whose main content is von Willebrand factor (vWF). The biogenesis of …

Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …