Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy
delivery in the clinic. Viral vectors, however, have certain issues involving genome …

We reassess progress in the field of biomolecular modeling and simulation, following up on
our perspective published in 2011. By reviewing metrics for the field's productivity and …

The oxDNA model of Deoxyribonucleic acid has been applied widely to systems in biology,
biophysics and nanotechnology. It is currently available via two independent open source …

Almost all nucleoprotein interactions and DNA manipulation events involve mechanical
deformations of DNA. Extraordinary progresses in single-molecule, structural, and …

The three-dimensional organization of DNA is increasingly understood to play a decisive
role in vital cellular processes. Many studies focus on the role of DNA-packaging proteins …

Thursday, February 25, 2021 221a sequences to superhelical apices. Base pair disruption
allows sharp bending at superhelical apices, which facilitates DNA writhing and, thus …

Abstract Structure and deformability of the DNA double helix play a key role in protein and
small ligand binding, in genome regulation via looping, or in nanotechnology applications …

DNA in cells is organized in negatively supercoiled loops. The resulting torsional and
bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes. This interplay …

Early studies of transcriptional regulation focused on individual gene promoters defined
specific transcription factors as central agents of genetic control. However, recent genome …

The integration host factor (IHF) is a prominent example of indirect readout as it imposes one
of the strongest bends on relaxed linear DNA. However, the relation between IHF and …