TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Brain tumors represent the second most frequent etiology in patients with focal seizure onset
before 18 years of age and submitted to epilepsy surgery. Hence, this category of brain …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …

Purpose BRAF V600 mutations are frequently found in several glioma subtypes, including
pleomorphic xanthoastrocytoma (PXA) and ganglioglioma and much less commonly in …

Gliomas form a heterogeneous group of tumors of the central nervous system (CNS) and are
traditionally classified based on histologic type and malignancy grade. Most gliomas, the …

IDH wild type (IDH wt) anaplastic astrocytomas WHO grade III (AA III) are associated with
poor outcome. To address the possibilities of molecular subsets among astrocytoma or of …

Purpose To uncover the genetic events leading to transformation of pediatric low-grade
glioma (PLGG) to secondary high-grade glioma (sHGG). Patients and Methods We …

Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for
approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known …

Gliomas are molecularly heterogeneous brain tumors responsible for the most years of life
lost by any cancer. High-grade gliomas have a poor prognosis and despite multimodal …

Every fourth patient submitted to epilepsy surgery suffers from a brain tumor.
Microscopically, these neoplasms present with a wide-ranging spectrum of glial or glio …