Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts
as a true click chemistry reaction allowing densely functional molecular fragments to be …

Cyclic peptides have been attracting a lot of attention in recent decades, especially in the
area of drug discovery, as more and more naturally occurring cyclic peptides with diverse …

Click chemistry is an approach that uses efficient and reliable reactions, such as Cu (I)-
catalyzed azide–alkyne cycloaddition (CuAAC), to bind two molecular building blocks …

A series of novel sulfanilamide-derived 1, 2, 3-triazole compounds were synthesized in
excellent yields via 1, 3-dipolar cycloaddition and confirmed by MS, IR and NMR spectra as …

The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly
applicable and easy-to-handle reactions in the arsenal of organic chemistry. However, the …

Through controlled synthesis and molecular assembly, biological systems are able to
organize molecules into supramolecular structures that carry out sophisticated processes …

Click chemistry is an efficient and chemoselective synthetic method for coupling molecular
fragments under mild reaction conditions. Since the advent in 2001 of methods to improve …

This tutorial review examines recent developments involving use of Copper-catalyzed Azide-
Alkyne [3+ 2] Cycloaddition (CuAAC) reactions in the synthesis, modification, and …

Click chemistry offers highly selective and orthogonal reactions that proceed rapidly and
under a variety of mild conditions with the opportunity to create highly defined and …