Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19

C Bruzzone, R Conde, N Embade, JM Mato… - Frontiers in Molecular …, 2023 - frontiersin.org
COVID-19 currently represents one of the major health challenges worldwide. Albeit its
infectious character, with onset affectation mainly at the respiratory track, it is clear that the …

Diagnostic, prognostic and mechanistic biomarkers of COVID-19 identified by mass spectrometric metabolomics

M Bourgin, S Durand, G Kroemer - Metabolites, 2023 - mdpi.com
A number of studies have assessed the impact of SARS-CoV-2 infection and COVID-19
severity on the metabolome of exhaled air, saliva, plasma, and urine to identify diagnostic …

Multi-omics reveals mechanisms of partial modulation of COVID-19 dysregulation by glucocorticoid treatment

M Spick, A Campbell, I Baricevic-Jones… - International journal of …, 2022 - mdpi.com
Treatments for COVID-19 infections have improved dramatically since the beginning of the
pandemic, and glucocorticoids have been a key tool in improving mortality rates. The UK's …

Electronic Tongue for Direct Assessment of SARS-CoV-2-Free and Infected Human Saliva—A Feasibility Study

M Falk, C Psotta, S Cirovic, L Ohlsson, S Shleev - Biosensors, 2023 - mdpi.com
An electronic tongue is a powerful analytical instrument based on an array of non-selective
chemical sensors with a partial specificity for data gathering and advanced pattern …

[HTML][HTML] Untargeted saliva metabolomics by liquid chromatography—Mass spectrometry reveals markers of COVID-19 severity

CF Frampas, K Longman, M Spick, HM Lewis… - PLoS …, 2022 - journals.plos.org
Background The COVID-19 pandemic is likely to represent an ongoing global health issue
given the potential for new variants, vaccine escape and the low likelihood of eliminating all …

Human Serum and Salivary Metabolomes: Diversity and Closeness

E Ferrari, M Gallo, A Spisni, R Antonelli… - International Journal of …, 2023 - mdpi.com
Saliva, which contains molecular information that may reflect an individual's health status,
has become a valuable tool for discovering biomarkers of oral and general diseases. Due to …

Visual diagnosis of COVID-19 disease based on serum metabolites using a paper-based electronic tongue

MM Bordbar, H Samadinia, A Sheini, J Aboonajmi… - Analytica Chimica …, 2022 - Elsevier
This study aims to use a paper-based sensor array for point-of-care detection of COVID-19
diseases. Various chemical compounds such as nanoparticles, organic dyes and metal ion …

The effects of hospitalisation on the serum metabolome in COVID-19 patients

T Hensen, D Fässler, L O'Mahony, WC Albrich, B Barda… - Metabolites, 2023 - mdpi.com
COVID-19, a systemic multi-organ disease resulting from infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is known to result in a wide array of …

[HTML][HTML] Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study

A English, D McDaid, SM Lynch… - JMIR Research …, 2024 - researchprotocols.org
Background: Health organizations and countries around the world have found it difficult to
control the spread of COVID-19. To minimize the future impact on the UK National Health …

A high throughput immuno-affinity mass spectrometry method for detection and quantitation of SARS-CoV-2 nucleoprotein in human saliva and its comparison with RT …

D Lane, R Allsopp, CW Holmes… - Clinical Chemistry and …, 2024 - degruyter.com
Objectives Many reverse transcription polymerase chain reaction (RT-PCR) methods exist
that can detect SARS-CoV-2 RNA in different matrices. RT-PCR is highly sensitive, although …