The dissemination of cancer cells from the primary tumor to a distant site, known as
metastasis, is the main cause of mortality in cancer patients. Metastasis is a very complex …

Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

Podosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells,
certain transformed fibroblasts and carcinoma cells and have recently also been discovered …

The plasma membrane of many motile cells undergoes highly regulated protrusions and
invaginations that support the formation of podosomes, invadopodia and circular dorsal …

Ventral stress fibers and focal adhesions are physically coupled structures that play key
roles in cellular mechanics and force sensing. The tight functional interdependence between …

Over the past decade, extensive research has focused on identifying the molecular
mechanisms and signal transduction pathways involved in the modulation of vascular …

Vascular smooth muscle cells (VSMCs) are able to perform both contractile and synthetic
functions, which are associated with changes in morphology, proliferation, and migration …

Stress fibres are contractile acto‐myosin structures found from many types of non‐muscle
cells, where they are involved in adhesion, motility and morphogenesis. Stress fibres …

Transgelin is a shape change sensitive 22kDa actin-binding protein of the calponin family. It
contains a C-terminal calponin-like module (CLIK23) and an upstream positively charged …

Since its discovery in the early 1990's, cortactin has emerged as a key signaling protein in
many cellular processes, including cell adhesion, migration, endocytosis, and tumor …