[HTML][HTML] A guide to vaccinology: from basic principles to new developments
AJ Pollard, EM Bijker - Nature Reviews Immunology, 2021 - nature.com
Immunization is a cornerstone of public health policy and is demonstrably highly cost-
effective when used to protect child health. Although it could be argued that immunology has …
effective when used to protect child health. Although it could be argued that immunology has …
Innate immune memory of tissue-resident macrophages and trained innate immunity: Re-vamping vaccine concept and strategies
In the past few years, our understanding of immunological memory has evolved remarkably
due to a growing body of new knowledge in innate immune memory and immunity …
due to a growing body of new knowledge in innate immune memory and immunity …
Tuberculosis vaccine development: progress in clinical evaluation
Tuberculosis (TB) is the leading killer among all infectious diseases worldwide despite
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
extensive use of the Mycobacterium bovis bacille Calmette-Guérin (BCG) vaccine. A safer …
IFN-γ independent markers of Mycobacterium tuberculosis exposure among male South African gold miners
LRL Davies, MT Smith, D Cizmeci, S Fischinger… - …, 2023 - thelancet.com
Background The prevalence of tuberculosis among men who work in the gold mines of
South Africa is among the highest in the world, but a fraction of miners demonstrate …
South Africa is among the highest in the world, but a fraction of miners demonstrate …
BCG‐induced protection against Mycobacterium tuberculosis infection: Evidence, mechanisms, and implications for next‐generation vaccines
M Foster, PC Hill, TP Setiabudiawan… - Immunological …, 2021 - Wiley Online Library
The tuberculosis (TB) vaccine Bacillus Calmette‐Guérin (BCG) was introduced 100 years
ago, but as it provides insufficient protection against TB disease, especially in adults, new …
ago, but as it provides insufficient protection against TB disease, especially in adults, new …
[HTML][HTML] Trained innate immunity and resistance to Mycobacterium tuberculosis infection
Background Some individuals, even when heavily exposed to an infectious tuberculosis
patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early …
patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early …
Early Clearance of Mycobacterium tuberculosis Is Associated With Increased Innate Immune Responses
AJ Verrall, M Schneider, B Alisjahbana… - The Journal of …, 2020 - academic.oup.com
Background A proportion of tuberculosis (TB) case contacts do not become infected, even
when heavily exposed. We studied the innate immune responses of TB case contacts to …
when heavily exposed. We studied the innate immune responses of TB case contacts to …
The knowns and unknowns of latent Mycobacterium tuberculosis infection
WH Boom, UE Schaible… - The Journal of clinical …, 2021 - Am Soc Clin Investig
Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …
Airway macrophages mediate mucosal vaccine–induced trained innate immunity against Mycobacterium tuberculosis in early stages of infection
Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis (TB), is
responsible for millions of infections and deaths annually. Decades of TB vaccine …
responsible for millions of infections and deaths annually. Decades of TB vaccine …
Natural resistance against infections: focus on COVID-19
MG Netea, J Domínguez-Andrés… - Trends in …, 2022 - cell.com
Not all individuals exposed to a pathogen develop illness: some are naturally resistant
whereas others develop an asymptomatic infection. Epidemiological studies suggest that …
whereas others develop an asymptomatic infection. Epidemiological studies suggest that …