Impact of risk factors on early cancer evolution

CE Weeden, W Hill, EL Lim, E Grönroos, C Swanton - Cell, 2023 - cell.com
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Papillomavirus immune evasion strategies target the infected cell and the local immune system

C Zhou, ZK Tuong, IH Frazer - Frontiers in oncology, 2019 - frontiersin.org
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

[HTML][HTML] The human papillomavirus (HPV)-related cancer biology: An overview

RP Araldi, TA Sant'Ana, DG Módolo, TC de Melo… - Biomedicine & …, 2018 - Elsevier
Despite the novel diagnostic methods and therapies implemented in oncology, the number
of patients that succumb by the cancer remains high globally. Currently studies point out that …

Cyclooxygenase-1 (COX-1) and COX-1 inhibitors in cancer: A review of oncology and medicinal chemistry literature

A Pannunzio, M Coluccia - Pharmaceuticals, 2018 - mdpi.com
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

New insights in the pathogenesis of HPV infection and the associated carcinogenic processes: the role of chronic inflammation and oxidative stress

SR Georgescu, CI Mitran, MI Mitran… - Journal of …, 2018 - Wiley Online Library
Human papillomavirus (HPV) is a small double‐stranded DNA virus with tropism for
epithelial cells. To this date, over 150 genotypes are known and are classified into two major …

Link between chronic inflammation and human papillomavirus-induced carcinogenesis

JV Fernandes… - Oncology …, 2015 - spandidos-publications.com
Inflammation is a defense strategy against invading agents and harmful molecules that is
activated immediately following a stimulus, and involves the release of cytokines and …

HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress

VM Williams, M Filippova, U Soto… - Future …, 2011 - Taylor & Francis
HPV-DNA integration into cellular chromatin is usually a necessary event in the
pathogenesis of HPV-related cancer; however, the mechanism of integration has not been …

Multi-omics characterization of silent and productive HPV integration in cervical cancer

J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …

HPV and DNA methylation testing in urine for cervical intraepithelial neoplasia and cervical cancer detection

R van den Helder, RDM Steenbergen… - Clinical Cancer …, 2022 - AACR
Purpose: Biomarker detection in urine offers a potential solution to increase effectiveness of
cervical cancer screening programs by attracting nonresponders. In this prospective study …

Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?

M Dellino, E Cascardi, AS Laganà, G Di Vagno… - Infectious agents and …, 2022 - Springer
Background Recent studies have shown the importance of the microbiota in women's health.
Indeed, the persistence of Human Papilloma Virus (HPV)-related lesions in patients with …